[Ip-health] PAHO recommends 4-7 R&D projects for consideration in December WHO meeting

Claire Cassedy claire.cassedy at keionline.org
Thu Oct 24 08:24:08 PDT 2013


http://keionline.org/node/1819

PAHO recommends 4-7 R&D projects for consideration in December WHO meeting

According to persons involved in the negotiations, PAHO will forward from
four to seven R&D demonstration projects to the WHO, for consideration at
the December meeting. The projects were selected from 29 that had been
proposed. Some rough notes on the 29 projects are available here:
http://goo.gl/8AiJQi. The projects were supposed to address new models for
financing open innovation, delinking R&D costs from product price. The
relevant WHO resolutions include WHA66.22 and the decision points in
A66/Div/3, attached below.

(For backgound on the consultations, see this PAHO page in English:
http://goo.gl/J9hd2B or Spanish: http://goo.gl/2s9S1j.)

If the WHO only accepts four proposals, they will be:

1.  [DNDi] Chagas R&D Accelerator Initiative: A Coordination Mechanism For
Accelerating The Development Of New Health Tools For Chagas Disease
2.  [Doctors without Borders/MSF]. The Open Source Multiplex POC Fever
Diagnostic Project
3.  [Oswaldo Cruz Foundation, Ministry of Health, Brazil] Development Of A
Vaccine Against Schistosomiasis Based On The Recombinant Sm14 A Member Of
The Fatty Acid Binding Protein: Controlling Transmission Of A Disease Of
Poverty.
4.  [US FDA & others] Development Of Class D Cpg Odn (D35) As An Adjunct To
Chemotherapy For Cutaneous Leishmaniasis And Post Kala- Azar Dermal
Leishmaniasis (Pkdl)

In case more projects are accepted, PAHO Member States recommend that the
next 3 projects should be included in this order:

1.  [Ministry of Health and Social Protection, Colombia, 2. Administrative
Department of Science and Technology, Colombia, 3. Knowledge Ecology
International] Affordable Diagnostic Tests For Cancer
2.  [Doctors without Borders/MSF] Accelerating Innovation And Access To
Medicines For Tuberculosis Through Open Collaboration: A Push, Pull, Pool
Approach
3.  [Ministry of Health, Brazil] Establishment Of Public-Private
Partnership For The Development Of A Diagnostic Kit For Prenatal And
Postpartum

Links to of all 7 of the projects are given at the end of this blog or can
be accessed via the post on KEI's website.

According to persons involved in the negotiations, the United States,
represented by Dr. Karl Western from NIH/NIAID and Peter Mamacos from DHHS,
sought to block the Colombia/KEI open source cancer diagnostics prize fund
proposal (attached here: http://goo.gl/w69eJ9), as well as the MSF TB
proposal.

The KEI/Colombia open source cancer diagnostics prize fund proposal had a
good deal of support among the PAHO members with the exception of the USA.

Note that among the 29 R&D proposals under consideration, 9 addressed
cancer, and the USA opposed all 9 cancer proposals.

Also worth noting is the fact that many proposals addressed the need for
better diagnostics technologies that can be used in resource poor settings.
This may reflect (1) the growing recognition that diagnostics are a key
element of health systems, (2) there are opportunities for innovations in
diagnostics, particularly as it relates to resource poor settings, and (3)
that the R&D costs associated with diagnostics are generally lower than for
drug development, and people are trying to be realistic about the resources
available for the demonstration projects.

KEI has asked Karl Western of the NIH/NIAID to explain why the NIH strongly
opposed the open source cancer diagnostics proposal. Since the NIH also
opposed the MSF proposal on TB treatment regimes, it seems as though the
NIH was basically trying to limit the proposals to "Type III" diseases
only, excluding all Type 1 and Type 2 diseases. (See WHO disease
definitions here: http://goo.gl/E5FiOD)

Some of the other regional consultations are not yet finished. For example,
the deadlines for submitting proposals are as follows: EMRO: October 30,
EURO October 31, and WPRO November 1.

The WHO Geneva meetings in on the R&D demonstration projects are currently
scheduled to take place from December 3 to December 5.

[1]
http://keionline.org/sites/default/files/OpenSourceCancerDiagnosticsPAHO3Sep2013.pdf
[2]
http://keionline.org/sites/default/files/WHO_definitions_Types1-3_14Nov2012.pdf
[3] http://keionline.org/sites/default/files/A66_DIV3-en.pdf
[4] http://keionline.org/sites/default/files/WHA66.22_CEWG.pdf
[5] http://keionline.org/sites/default/files/BRMOH_KIT_PAHO.pdf
[6] http://keionline.org/sites/default/files/OswaldoCruz_Schistosomiasis.pdf
[7] http://keionline.org/sites/default/files/MSF_TB_PAHO.pdf
[8] http://keionline.org/sites/default/files/MSF_Fever_PAHO.pdf
[9] http://keionline.org/sites/default/files/FDA_Leishmaniasis_PAHO.pdf
[10] http://keionline.org/sites/default/files/DNDi_Chagas_PAHO.pdf



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