[Ip-health] United States Patent: 9745368

Michael H Davis m.davis at csuohio.edu
Fri Sep 1 18:27:06 PDT 2017


You couldn't be more right.
Mickey Davis



Sent from my T-Mobile 4G LTE Device


-------- Original message --------
From: Jamie Love <james.love at keionline.org>
Date: 9/1/17 19:38 (GMT-05:00)
To: Ip-health <ip-health at lists.keionline.org>
Subject: [Ip-health] United States Patent: 9745368

​Novartis and the University of Pennsylvania ​were granted a CAR T patent
on Tuesday, August 29.  This patent, like others, discloses federal
Bayh-Dole rights in the invention.

It appears that Kymriah, the $475,000 Novartis CAR T treatment, will be
subject to royalty free and march-in rights, and a statutory obligation to
make the invention "available to the public on reasonable terms."

Jamie

​-------------------​
​
​
Government Interests

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

This invention was made with government support under PN2 EY016586 awarded
by the National Institutes of Health (NIH). The government has certain
rights in the invention.


​-------------------

​US Patent Number ​
9,745,368

August 29, 2017

Targeting cytotoxic cells with chimeric receptors for adoptive
immunotherapy

Abstract
The present invention provides compositions and methods for regulating the
specificity and activity of T cells. In one embodiment, the invention
provides a type of chimeric antigen receptor(CAR) wherein the CAR is termed
a "KIR-CAR" which is a CAR design comprising a component of a receptor
naturally found on natural killer (NK) cells. In one embodiment, the NK
receptor includes but is not limited to a naturally occurring activating
and inhibitory receptor of NK cells known as a killer cell
immunoglobulin-like receptor (KIR).​


Inventors:
​ ​
Milone; Michael C. (Cherry Hill, NJ), Wang; Enxiu (Upper Darby, PA)

Applicant:
​ ​
Novartis AG
​, Basel, ​
The Trustees of the University of Pennsylvania
​, ​
Philadelphia

Assignee:
The Trustees of the University of Pennsylvania (Philadelphia, PA)
Novartis AG (Basel, CH)


​
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