[Vaccine-manufacturing] New York Times: How Europe Sealed a Pfizer Vaccine Deal With Texts and Calls

Thiru Balasubramaniam thiru at keionline.org
Wed Apr 28 01:28:50 PDT 2021


https://www.nytimes.com/2021/04/28/world/europe/european-union-pfizer-von-der-leyen-coronavirus-vaccine.html

<SNIP>


It was at that low point that she caught a break.

For a month, Ms. von der Leyen had been exchanging texts and calls with
Albert Bourla, the chief executive of Pfizer, another vaccine supplier to
the bloc. And as they spoke, two things became clear: Pfizer might have
more doses it could offer the bloc — many more. And the European Union
would be thrilled to have them.

That personal diplomacy played a big role in a deal, to be finalized this
week, in which the European Union will lock in 1.8 billion doses from
Pfizer, which, with its smaller German partner, BioNTech, made the first
Covid-19 vaccine to get regulatory approval in the European Union.

The new contract will include a 900-million-dose order through 2023, with
an option for another 900 million, Ms. von der Leyen said in an interview.

“I am convinced that we are in this for the long haul,” she said.

The deal will establish the European Union as Pfizer’s biggest single
client by far; the company has so far sold 300 million doses to the United
States. The contract will permit the European Union to resell or donate the
vaccines to partners, empowering it to conduct vaccine diplomacy and
support struggling efforts to immunize people in poorer countries.

<SNIP>


The agreement with Pfizer and BioNTech will stipulate that the shots be
produced in Europe, bringing home not just the finished product, but also
most of the 280 components that go into making it, Ms. von der Leyen and
Mr. Bourla of Pfizer said.

The contract will also allow for a range of different vaccine products.

An internal European Commission assessment of the bloc’s needs over the
next two years, which is still being reviewed and was seen by The Times,
lays out ballpark figures for how many doses might be necessary under
different scenarios, although not all these needs would necessarily be
covered by the Pfizer contract. According to the draft assessment, the bloc
might require up to 510 million booster doses in 2022 and 2023.

Mr. Bourla said he expected a booster would be needed six to twelve months
after people get their second shot, although some public health experts
note that it is not clear yet whether that will be necessary. And the
assessment includes a worst-case scenario for a new vaccine to target an
“escape mutant,” a variant of the coronavirus that is too resistant to
existing shots. The draft says the European Union would require 640 million
doses of this type of vaccine for two doses per adult. And it puts the
number of pediatric vaccines at 130 million for 2022 and 65 million for
2023.

The deal is not without risks, or critics. Countries and experts worry that
the European Union may be becoming too dependent on Pfizer, and failing to
hedge its bets in the event of problems with the vaccine or its production.

<SNIP>

--

How Europe Sealed a Pfizer Vaccine Deal With Texts and Calls

The European Union is about to sign a deal for 1.8 billion doses of the
Pfizer-BioNTech vaccine after a dispute with AstraZeneca derailed its
vaccination campaign. Here’s how it came about.

By Matina Stevis-Gridneff
April 28, 2021Updated 3:29 a.m. ET

BRUSSELS — It was February and things were going from bad to worse for the
European Union’s vaccination campaign, and for its top executive, Ursula
von der Leyen.

Much of Europe was in lockdown, people were dying and the bloc was running
low on doses of vaccines after its biggest supplier, AstraZeneca, announced
production problems. Critics inside and outside the European Union
questioned Ms. von der Leyen’s leadership and accused her of mishandling
the crisis.

It was at that low point that she caught a break.

For a month, Ms. von der Leyen had been exchanging texts and calls with
Albert Bourla, the chief executive of Pfizer, another vaccine supplier to
the bloc. And as they spoke, two things became clear: Pfizer might have
more doses it could offer the bloc — many more. And the European Union
would be thrilled to have them.

That personal diplomacy played a big role in a deal, to be finalized this
week, in which the European Union will lock in 1.8 billion doses from
Pfizer, which, with its smaller German partner, BioNTech, made the first
Covid-19 vaccine to get regulatory approval in the European Union.

The new contract will include a 900-million-dose order through 2023, with
an option for another 900 million, Ms. von der Leyen said in an interview.

“I am convinced that we are in this for the long haul,” she said.

The deal will establish the European Union as Pfizer’s biggest single
client by far; the company has so far sold 300 million doses to the United
States. The contract will permit the European Union to resell or donate the
vaccines to partners, empowering it to conduct vaccine diplomacy and
support struggling efforts to immunize people in poorer countries.


Ms. von der Leyen and Mr. Bourla first connected in January, when the
pharmaceutical boss had to explain why his company had to cut vaccine
supplies temporarily while it upgraded manufacturing facilities in Belgium.
In November, the European Union signed an initial deal with the company for
200 million doses, with the option to add 100 million.

As the improvements at the Belgium plant moved along with relative ease,
the discussions between the E.U. leader and the pharmaceutical chief
continued, both recounted in interviews with The New York Times.

As they talked, the pandemic was raging across Europe, and Pfizer and
BioNTech were hard at work trying to step up production. To increase the
companies’ production capacity even further, the chief commercial officer
at BioNTech, Sean Marett, was lining up regulatory approval for a newly
acquired plant in Germany, which was already producing vaccines and
stockpiling them in anticipation of getting a green light.


The calls resulted in a string of deals between the European Union and the
companies. On Feb. 17, the bloc announced an order for another 200 million
shots. On April 19, it activated an option to get yet another 100 million.

Accounts of how the deals came about, related by Ms. von der Leyen, Mr.
Bourla, Mr. Marett and another nine officials and experts involved, reveal
a striking alignment of political survival and corporate hustle.

In her interview, Ms. von der Leyen played down the political pressures she
had faced, and said she had been confident things would improve.

“I knew that the upscaling of the deliveries would have a slow start by
nature in the beginning, and therefore, I also knew the first quarter was
going be tough,” she said. But, she added, “I did not expect it to be as
tough, because we did not include the possibility that AstraZeneca would
reduce deliveries by 75 percent. That was a heavy setback.”

Mr. Bourla said he built a bond with Ms. von der Leyen.

Mr. Bourla said he and Ms. von der Leyen had “developed a deep trust,
because we got into deep discussions.” He said: “She knew details about the
variants, she knew details about everything. So that made the discussion,
way more engaged.”

Despite the deals with Pfizer and BioNTech, Europe is still playing
catch-up when it comes to vaccinating its citizens. As of this week, 22
percent of European Union nationals have received at least one dose of a
Covid-19 vaccine, in contrast to half of Britons, 42 percent of Americans
and more than 62 percent of Israelis, according to Our World in Data.

But the European Union has now made up for the vaccine it did not get from
AstraZeneca — the bloc is suing over the missed doses — and has moved
forward its target date for getting 70 percent of its adults fully
immunized. It is now July, instead of September.

The bloc is already one of the world’s biggest producers and exporters of
Covid-19 vaccines, with just over 159 million doses shipped to 87 countries
since December. That is almost exactly as many as it has kept at home to
immunize its own people.

The agreement with Pfizer and BioNTech will stipulate that the shots be
produced in Europe, bringing home not just the finished product, but also
most of the 280 components that go into making it, Ms. von der Leyen and
Mr. Bourla of Pfizer said.

The contract will also allow for a range of different vaccine products.

An internal European Commission assessment of the bloc’s needs over the
next two years, which is still being reviewed and was seen by The Times,
lays out ballpark figures for how many doses might be necessary under
different scenarios, although not all these needs would necessarily be
covered by the Pfizer contract. According to the draft assessment, the bloc
might require up to 510 million booster doses in 2022 and 2023.

Mr. Bourla said he expected a booster would be needed six to twelve months
after people get their second shot, although some public health experts
note that it is not clear yet whether that will be necessary. And the
assessment includes a worst-case scenario for a new vaccine to target an
“escape mutant,” a variant of the coronavirus that is too resistant to
existing shots. The draft says the European Union would require 640 million
doses of this type of vaccine for two doses per adult. And it puts the
number of pediatric vaccines at 130 million for 2022 and 65 million for
2023.

The deal is not without risks, or critics. Countries and experts worry that
the European Union may be becoming too dependent on Pfizer, and failing to
hedge its bets in the event of problems with the vaccine or its production.

“I would caution against going for Pfizer/BioNTech only,” said Prof. Peter
Piot, a microbiologist who advises Ms. von der Leyen. “That is too high
risk for me, scientifically,” he said, though he noted that mRNA technology
vaccines like Pfizer’s have so far been working well.

Of the new E.U. deal with Pfizer, Professor Piot said, “My interpretation
is, what works is who can deliver.”

Ms. von der Leyen said the European Union could still procure doses from
other companies.

She said the bloc was following the development of protein-based vaccines
made by Novavax and Sanofi, as well as mRNA vaccines from Moderna, which
are already being used in Europe, and CureVac, which is under review by the
E.U. regulator. The Johnson & Johnson vaccine, which was rolled out in
Europe this month, is also attractive because of its single-dose regimen
and easy storage, she said.

The Pfizer shot is also expensive. While the financial details of the new
agreement have not been disclosed, the previous contract priced the shot at
approximately 15.5 euros, or about 19 dollars, making it the second-most
expensive vaccine in the region after Moderna.

European Union members will each decide whether they want to use their full
allocations of doses, or leave some for others to absorb, or to be resold
or donated. They will also be free to make bilateral agreements with other
pharmaceutical companies for vaccines in the future.

The new contract does little to address mounting global calls for the
release of patents or for technology transfers to ensure that more of the
world gets vaccinated soon. With India in the throes of a catastrophic wave
of the virus, and the majority of the world’s population still far from
getting access to a first dose of any vaccine, Europe’s talk of doses for
children and boosters seems out of step with global needs, health experts
say.

And while Ms. von der Leyen says the deal will enable the European Union to
help poorer regions, it reinforces the fact that the rich are still coming
first in the global scramble for vaccines.

Siddartha Sankar Datta, a senior official with the World Health
Organization in Europe, said he worried about how the deal would affect
global supply.

“I think the bottom line should be that the access to this vaccine should
not be a prerogative of the purchasing power of the country,” he said. He
said, “As countries make the effort to ensure their population base gets
benefits, we have to still keep pushing ourselves to ensure more equitable
access.”

Still, for Ms. von der Leyen, and for the European Union, the deal with
Pfizer and BioNTech offers a chance to remedy past mistakes.

“Europe has decided to make sure that, under any circumstances, they will
be prepared if there’s more need, and as a consequence of that political
decision, they are now prepared to take much bigger risks,” said Moncef
Slaoui, who led the U.S. vaccine effort Operation Warp Speed, and is in
frequent contact with Ms. von der Leyen on E.U. strategy.

“Politics and science are intertwined here,” he said.

Matina Stevis-Gridneff is the Brussels correspondent for The New York
Times, covering the European Union. She joined The Times after covering
East Africa for The Wall Street Journal for five years. @MatinaStevis

A version of this article appears in print on April 28, 2021, Section A,
Page 4 of the New York edition with the headline: Diplomacy Behind Europe’s
Deal With Pfizer. Order Reprints | Today’s Paper | Subscribe


-- 
Thiru Balasubramaniam
Geneva Representative
Knowledge Ecology International
41 22 791 6727
thiru at keionline.org


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