[Ip-health] NICE says Gilead price for CAR T treatment Yescarta is too expensive

Michael H Davis m.davis at csuohio.edu
Tue Aug 28 11:53:53 PDT 2018


Let's face it. This is just a matter of political will.



Sent from my T-Mobile 4G LTE Device


-------- Original message --------
From: James Love <james.love at keionline.org>
Date: 8/28/18 09:49 (GMT-05:00)
To: Ip-health <ip-health at lists.keionline.org>
Subject: [Ip-health] NICE says Gilead price for CAR T treatment Yescarta is too expensive

The UK's National Institute for Health and Care Excellence (NICE) has a
preliminary rejection of a Gilead's price for Yescarta, a CAR T technology
invented by the NIH and licensed to Kite/Gilead.

What this means is that a technology invented by the NIH and licensed to
Kite/Gilead, is so expensive patients in the UK won't have access.

https://www.nice.org.uk/guidance/GID-TA10214/documents/appraisal-consultation-document

This is the Reuters story about the NICE decision.  Note that this year the
NIH proposed licensing another CAR T treatment to Gilead, and rejected all
of KEI requests for conditions addressing pricing and access.  (A case
still in litigation).


(Best to read this on the Rueters web page, so the reporters and publishers
see the traffic).

https://in.reuters.com/article/us-gilead-sciences-britain/uk-rejects-gileads-car-t-cancer-cell-therapy-as-too-expensive-idINKCN1LD16V

AUGUST 28, 2018
UK rejects Gilead's CAR-T cancer cell therapy as too expensive
Ben Hirschler

LONDON (Reuters) - A cutting-edge CAR-T cell therapy for otherwise
untreatable forms of blood cancer is too expensive to justify its use on
Britain’s state-funded health service, the country’s healthcare cost agency
NICE said on Tuesday.

The decision by the National Institute for Health and Care Excellence
(NICE) is a blow to U.S. drugmaker Gilead Sciences, which wants to get its
Yescarta product approved for use on the National Health Service (NHS).

The NICE rejection comes one day after the European Commission approved
Yescarta for two aggressive forms of non-Hodgkin lymphoma. That green light
cleared the way for each European country to decide on whether to fund the
treatment.

Yescarta is the first CAR-T therapy to be assessed by NICE. The agency is
currently appraising Novartis’s rival Kymriah, which also won EU approval
on Monday. NICE experts met last week to consider initial recommendations
on the Swiss firm’s product, a spokesman said.

Both Yescarta and Kymriah are chimeric antigen receptor T-cell therapies,
or CAR-Ts, which reprogram the body’s own immune cells to attack malignant
cells.

The treatments represents a brand new approach to fighting cancer, since
the therapy involves extraction of infection-fighting cells from a patient.
These cells are then genetically engineered to recognize cancer cells and
infused back.

The process is complex and expensive but it offers hope for people with
certain kinds of blood cancer who have exhausted all other treatment
options.

Meindert Boysen, director of the center for health technology evaluation at
NICE, said Yescarta was “an exciting innovation in very difficult to treat
cancers, with a promise of cure for some patients” but said its price was
too high for it to be considered cost-effective.

The U.S. list price for Yescarta is $373,000. The UK price is confidential.
NICE said Gilead had proposed a “commercial arrangement” if Yescarta was
recommended. Typically, drugmakers provide price discounts in exchange for
NHS access.

Gilead said it was “in ongoing discussions with NICE to identify
appropriate treatment comparators which can clarify how cell therapy may be
made available to patients in the UK”.

Raj Chopra, head of cancer therapeutics at the Institute of Cancer Research
in London, said the NICE rejection was disappointing for patients.

“If we’re going to see CAR-T therapy widely available on the NHS, we need
to find ways to reduce the costs,” he said.

Yescarta was approved by the U.S. Food and Drug Administration in October.


Reporting by Ben Hirschler; Editing by Edmund Blair


--
James Love.  Knowledge Ecology International
http://www.keionline.org <http://www.keionline.org/donate.html>
twitter.com/jamie_love
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